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recombinant human hbegf  (R&D Systems)


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    R&D Systems recombinant human hbegf
    Recombinant Human Hbegf, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 168 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/recombinant human hbegf/product/R&D Systems
    Average 93 stars, based on 168 article reviews
    recombinant human hbegf - by Bioz Stars, 2026-02
    93/100 stars

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    (A to D) Intracellular Ca2+ concentration in mouse male and female DRG neurons in response to <t>HBEGF</t> (A, analyzed in B) or HBEGF with the EGFR antagonist lapatinib (C, analyzed in D). N = 306 and 595 neurons, respectively. (E to J) Mechanical sensitivity to von Frey filaments, as inferred from paw withdrawal thresholds and grimacing, in male ICR mice (E and F) and female C57BL/6 mice (G and H) one hour after hindpaw injection with saline or 50 ng HBEGF. Pooled data for all male and female are displayed in (I and J). N = 5 to 11 mice each, as noted in the figure. * p <0.05, ** p<0.01, *** p<0.001 by two-way ANOVA with Bonferroni post test, or t-test for effect size. Sample sizes are shown in the figure. Horizontal bars or boxes represent the mean, and error bars represent SEM.
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    (A to D) Intracellular Ca2+ concentration in mouse male and female DRG neurons in response to <t>HBEGF</t> (A, analyzed in B) or HBEGF with the EGFR antagonist lapatinib (C, analyzed in D). N = 306 and 595 neurons, respectively. (E to J) Mechanical sensitivity to von Frey filaments, as inferred from paw withdrawal thresholds and grimacing, in male ICR mice (E and F) and female C57BL/6 mice (G and H) one hour after hindpaw injection with saline or 50 ng HBEGF. Pooled data for all male and female are displayed in (I and J). N = 5 to 11 mice each, as noted in the figure. * p <0.05, ** p<0.01, *** p<0.001 by two-way ANOVA with Bonferroni post test, or t-test for effect size. Sample sizes are shown in the figure. Horizontal bars or boxes represent the mean, and error bars represent SEM.
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    (A to D) Intracellular Ca2+ concentration in mouse male and female DRG neurons in response to HBEGF (A, analyzed in B) or HBEGF with the EGFR antagonist lapatinib (C, analyzed in D). N = 306 and 595 neurons, respectively. (E to J) Mechanical sensitivity to von Frey filaments, as inferred from paw withdrawal thresholds and grimacing, in male ICR mice (E and F) and female C57BL/6 mice (G and H) one hour after hindpaw injection with saline or 50 ng HBEGF. Pooled data for all male and female are displayed in (I and J). N = 5 to 11 mice each, as noted in the figure. * p <0.05, ** p<0.01, *** p<0.001 by two-way ANOVA with Bonferroni post test, or t-test for effect size. Sample sizes are shown in the figure. Horizontal bars or boxes represent the mean, and error bars represent SEM.

    Journal: Science signaling

    Article Title: A ligand-receptor interactome platform for discovery of pain mechanisms and therapeutic targets

    doi: 10.1126/scisignal.abe1648

    Figure Lengend Snippet: (A to D) Intracellular Ca2+ concentration in mouse male and female DRG neurons in response to HBEGF (A, analyzed in B) or HBEGF with the EGFR antagonist lapatinib (C, analyzed in D). N = 306 and 595 neurons, respectively. (E to J) Mechanical sensitivity to von Frey filaments, as inferred from paw withdrawal thresholds and grimacing, in male ICR mice (E and F) and female C57BL/6 mice (G and H) one hour after hindpaw injection with saline or 50 ng HBEGF. Pooled data for all male and female are displayed in (I and J). N = 5 to 11 mice each, as noted in the figure. * p <0.05, ** p<0.01, *** p<0.001 by two-way ANOVA with Bonferroni post test, or t-test for effect size. Sample sizes are shown in the figure. Horizontal bars or boxes represent the mean, and error bars represent SEM.

    Article Snippet: Experimental Reagents Recombinant human HBEGF (259-HE) was purchased from R&D Systems and reconstituted to 50 μg/ml in 0.1% BSA.

    Techniques: Concentration Assay, Injection, Saline